Tarbiat Modarres University School of Medicine researchers in a study to evaluate the effect of crocin and crocetin saffron on the expression of p53 and p27 in breast cancer tumors began.
According to ISNA Research Service, saffron not only as a spice, but also as a medicinal plant with diverse medical uses, is concerned. An important application is for these plants has proved its role in the treatment of various cancers.
Mahshid Azizian clinical biochemist also continued saying: crocetin and crocin saffron carotenoids are important anti-tumor and anti-cancer effects have been shown in various studies, but the exact molecular mechanism of action of these compounds to inhibit cancer are still unclear .
He said the increasing prevalence of breast cancer: Breast cancer is one of the most common cancers in women and 57 percent of them are dependent on estrogen. One of the causes of the imbalance between death and cancer cell proliferation through cell cycle. p35 is one of the most important genes involved in apoptosis and cell proliferation. p27-dependent Kinases inhibitors cyclone, which is also one of its activity leads to cell cycle arrest.
Azizian the purposes and objectives stated: Due to crocin and crocetin the previous study we have different effects on p12 activation in breast cancer tumors induced by UMN indicated, in order to clarify the mechanism of this effect, gene expression profiling P35 and P72 in this tumor was. RNA NMU-induced breast tumors and normal tissue was extracted female rats. P35 and P72 then gene expression in these samples was determined using RCP-TR.
He described his findings as follows: Compared with no treatment and samples treated with saffron carotenoids, increased expression of P35 gene expression in tumors in rats treated with crocetin, but decreased in tumors treated with crocin showed. Also, tumors decreased expression of P72 in rats treated with crocetin and crocin than rats without tumor was observed.
Tarbiat Modarres University researcher concluded by saying: crocetin and crocin P72 expression in breast cancer tumors induced by NMU reduce their impact on the P35 was different, but the findings are consistent with previous data we have about P12.
Additionally, the research doctor Syeda Zahra Bthayy guidance and advice of a doctor Mahboubeh Ashrafi of Tarbiat Modarres University’s faculty.
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