Some of the properties of saffron
Saffron, in addition to being a high-consumption food additive, has many pharmacological properties. We continue to pay attention to the holy month of Ramadan and to use more of this spice for its properties.
Saffron and antioxidant properties:
Saffron exerts its antioxidant effects by increasing the activity of the superoxide dismutase enzyme (SOD), which is one of the first line of defense of the cells against the toxicity of free radicals, according to Health News.
Because the enzyme is a potent antioxidant enzyme and protects the body from damage to superoxide produced by the toxic free radicals in mitochondria.
Superoxide dismutase is a key enzyme, because it plays a role in the first phase of free radicals removal.
Saffron and Cardiovascular Diseases:
Several studies have shown the effect of anti-aterosclerosis of saffron and its active ingredients, and many mechanisms, including antifungal, anticoagulant, inhibition of platelet aggregation, inhibition of foaming, inhibition of oxidized lipoprotein reuptake and inhibition of expression of adhesion factors, The inhibition of induction of apoptosis (planned cell death) of the endothelial cell, etc., has been shown to improve the health of the cardiovascular system of saffron.
On the other hand, the active active ingredient of saffron, crocin, can be useful in preventing and treating atherosclerosis by preventing the proliferation of smooth muscle cells in the aorta.
Saffron and Lipid profile:
Crocin saffron by inhibition of pancreatic lipase (as a competitive inhibitor) in the intestine increases the excretion of fat and cholesterol in the stool and thus decreases serum triglyceride, total cholesterol, low density lipoprotein cholesterol (LDL), and high density lipoprotein cholesterol Low (VLDL), which can also help prevent a variety of cardiovascular diseases.
Saffron and brain health:
Saffron can significantly reduce brain edema, which is one of the main causes of the development and spread of secondary damage after a stroke.
Animal studies have shown that crocin is an effective component of saffron, which has a protective effect against the destruction of blood-brain barrier after global cerebral ischemia.
Reducing the level of dexamethasal antioxidant activity, glutathione peroxidase, during local cerebral ischemia, may increase the sensitivity of neuronal cells to damaging agents such as the types of oxidants, free radicals, and the onset of planned cell death, Or maintaining the activity of the intrinsic surface of these enzymes by stimulating its increased synthesis may protect the cells against damage and death.
Saffron and Cancer:
Among the herbs that seem to play important roles in the treatment and control of diabetes, saffron can be named, which has its beneficial and effective effects in this area:
1- Stopping and inhibiting three important metabolic processes – making DNA, RNA and protein in cancerous cells.
2. The inhibitory effect on the free radical chain interactions. Because most of the saffron carotenoids (crocin, crocidine, and safranal) are soluble in fat and act as binding members for free radicals that are also associated with their antioxidant properties.
3. The antinociceptive effect of saffron, which naturally transforms carotenoids into rhenetidium.
4. The cytotoxic activity of saffron, interacting with the interaction of carotenoids with topoisomerase II, acts as an enzyme that interacts with the interaction of proteins and DNA and induces apoptosis of cancer cells.
Saffron and Depression:
Generally, saffron and its active ingredients can regulate the synthesis and secretion of neurotransmitters that are effective in creating the proper mental states or depression, which can be beneficial in this regard:
Saffronal in dose-dependent saffron produces serotonin-like effects and, by increasing concentrations, inhibits serotonin reuptake.
Inhibition of dopamine reuptake inhibition (a type of nerve transporter that decreases it with anxiety in the person) and norepinephrine by crocin in saffron.
The inhibition of the activity of the enzyme monoamine oxidase (MAO), an enzyme that destroys the brain of various neurotransmitters such as serotonin, epinephrine, dopamine.
Saffron and pain and inflammation:
Saffron extract inhibits cyclooxygenase type 2 (COX2) enzymes and thereby inhibits the production of prostaglandin E, and also nitric oxide synthase prevents the formation of nitric oxide (NO) at the site of inflammation, which can lead to anti-inflammatory and anti-inflammatory effects Get sick.
In addition, other components of saffron, such as flavonoids and carotenoids, have an antioxidant effect and, by trapping free radicals such as oxygen and superoxide radicals, inhibit the production of various prostaglandins. Therefore, one of the mechanisms of reducing the pain of saffron, is related to its antioxidant properties.
prohibited usage:
Saffron has no special side effects, but high levels of it in some people can cause vomiting, reduced heart rate, bleeding from the nose, bleeding from the eyelids and lips, headaches, lethargy, yellowing of the skin and other harmful effects.
In addition, the intake of excessive amounts in the first trimester of pregnancy can lead to fetal abnormalities, a negative effect on the fetal nervous system and even abortion.
source: zendegionline /ir
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